Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; response to hypoxia; and salivary gland morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including adult CNS glial cell; anal pad; germ layer; gut section; and imaginal disc. Orthologous to human HES1 (hes family bHLH transcription factor 1).
FB Description
hairy (hry) encodes a bHLH transcriptional repressor that recruits the corepressor encoded by gro to target promoters. It is a pair-rule gene that contributes to embryonic segmentation and peripheral neurogenesis.