Version: 8.0.0
Date: Tue Jan 28 2025
Jra
Drosophila melanogasterFB:FBgn0001291
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Jra

Species
Drosophila melanogaster
Symbol
Jra
Name
Jun-related antigen
Synonyms
  • activator protein 1
  • Ap-1
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein heterodimerization activity. Involved in several processes, including defense response to bacterium; egg chorion assembly; and imaginal disc fusion, thorax closure. Located in cytosol and nucleus. Part of transcription factor AP-1 complex. Is expressed in several structures, including amnioserosa primordium; dorsal ectoderm; epithelial cell; epithelium; and larval internal muscle motor neurons. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma; melanoma; and pulmonary tuberculosis. Orthologous to several human genes including JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) and JUND (JunD proto-oncogene, AP-1 transcription factor subunit).
FB Description
Jun-related antigen (Jra) encodes a homologue of the mammalian transcription factor Jun and has pleiotropic roles in the CNS. Jra activity is regulated by many upstream enzymes, including bsk.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11462
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            10.0966M10.0968M10.0970M10.0972M10.0974M10.0976M10.0978M10.0980M10.0982M10.0984M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Jra molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Jra role
              Jra genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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