Gene

Khc

Species
Drosophila melanogaster
Symbol
Khc
Name
Kinesin heavy chain
Synonyms
  • 2R6
  • CG7765
Biotype
protein coding gene
Automated Description
Enables microtubule binding activity; microtubule motor activity; and tropomyosin binding activity. Involved in several processes, including cytoskeleton organization; neuron differentiation; and oocyte axis specification. Located in actin cap; axon cytoplasm; and microtubule plus-end. Part of kinesin complex. Is expressed in several structures, including adult heart; germline cell; glial cell; head; and photoreceptor neurons. Used to study hereditary spastic paraplegia; motor neuron disease; neurodegenerative disease; and spinal muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including amyotrophic lateral sclerosis type 25; autoimmune disease (multiple); complex cortical dysplasia with other brain malformations 2; hereditary spastic paraplegia 10; and prostate cancer. Orthologous to several human genes including KIF5B (kinesin family member 5B).
FB Description
Kinesin heavy chain (Khc) encodes the force generating subunit of kinesin-1, a microtubule motor protein. It functions in the long-distance transport of cytoplasmic "cargoes" such as mRNAs, protein complexes, and organelles.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24115
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page

      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
      No records match query. Try removing filters.
      Showing 0 - 0 of 0 rows
      per page

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
        No records match query. Try removing filters.
        Showing 0 - 0 of 0 rows
        per page

          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
          No records match query. Try removing filters.
          Showing 0 - 0 of 0 rows
          per page

            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            16.2670M16.2675M16.2680M16.2685M16.2690M16.2695M16.2700M16.2705M16.2710M16.2715M

            Sequence Details

            Loading...

            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Khc molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
            No records match query. Try removing filters.
            Showing 0 - 0 of 0 rows
            per page

              Genetic Interactions

              Khc role
              Khc genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
              No records match query. Try removing filters.
              Showing 0 - 0 of 0 rows
              per page