Version: 8.0.0
Date: Tue Jan 28 2025
Khc
Drosophila melanogasterFB:FBgn0001308
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Khc

Species
Drosophila melanogaster
Symbol
Khc
Name
Kinesin heavy chain
Synonyms
  • 2R6
  • CG7765
Biotype
protein coding gene
Automated Description
Enables microtubule binding activity; microtubule motor activity; and tropomyosin binding activity. Involved in several processes, including cytoskeleton organization; neuron differentiation; and oocyte axis specification. Located in actin cap; axon cytoplasm; and microtubule plus-end. Part of kinesin complex. Is expressed in several structures, including adult heart; germline cell; glial cell; head; and photoreceptor neurons. Used to study hereditary spastic paraplegia; motor neuron disease; neurodegenerative disease; and spinal muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including amyotrophic lateral sclerosis type 25; autoimmune disease (multiple); complex cortical dysplasia with other brain malformations 2; hereditary spastic paraplegia 10; and prostate cancer. Orthologous to several human genes including KIF5B (kinesin family member 5B).
FB Description
Kinesin heavy chain (Khc) encodes the force generating subunit of kinesin-1, a microtubule motor protein. It functions in the long-distance transport of cytoplasmic "cargoes" such as mRNAs, protein complexes, and organelles.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24115
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Khc molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Khc role
            Khc genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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