Gene

l(3)mbt

Species
Drosophila melanogaster
Symbol
l(3)mbt
Name
lethal (3) malignant brain tumor
Synonyms
  • CG5954
  • dL(3)mbt
Biotype
protein coding gene
Automated Description
Enables chromatin insulator sequence binding activity. Involved in several processes, including negative regulation of macromolecule biosynthetic process; regulation of preblastoderm mitotic cell cycle; and syncytial nuclear migration. Located in cytoplasm; nucleus; and polytene chromosome. Part of Myb complex and RNA polymerase II transcription regulator complex. Is expressed in several structures, including cephalic furrow; embryonic/larval fat body; ganglia; gut section; and larval optic anlage. Used to study brain cancer. Orthologous to several human genes including L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3) and L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4).
FB Description
lethal (3) malignant brain tumor (l(3)mbt) encodes a tumor suppressor protein regulating proliferation in the brain, particularly the optic lobes. The proposed functions of the product of l(3)mbt include histone compaction, establishment of chromatin insulators, regulation of the Hippo pathway and repression of the germ line program in somatic cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12247
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
27.267M27.268M27.269M27.270M27.271M27.272M27.273M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions