Enables chromatin insulator sequence binding activity. Involved in several processes, including negative regulation of macromolecule biosynthetic process; regulation of preblastoderm mitotic cell cycle; and syncytial nuclear migration. Located in cytoplasm; nucleus; and polytene chromosome. Part of Myb complex and RNA polymerase II transcription regulator complex. Is expressed in several structures, including cephalic furrow; embryonic/larval fat body; ganglia; gut section; and larval optic anlage. Used to study brain cancer. Orthologous to several human genes including L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3) and L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4).
FB Description
lethal (3) malignant brain tumor (l(3)mbt) encodes a tumor suppressor protein regulating proliferation in the brain, particularly the optic lobes. The proposed functions of the product of l(3)mbt include histone compaction, establishment of chromatin insulators, regulation of the Hippo pathway and repression of the germ line program in somatic cells.