Version: 8.0.0
Date: Tue Jan 28 2025
Pfk
Drosophila melanogasterFB:FBgn0003071
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pfk

Species
Drosophila melanogaster
Symbol
Pfk
Name
Phosphofructokinase
Synonyms
  • 6-phosphofructokinase
  • BcDNA:GH12192
Biotype
protein coding gene
Automated Description
Enables 6-phosphofructokinase activity. Involved in several processes, including fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in cytosol and mitochondrion. Predicted to be part of 6-phosphofructokinase complex. Is expressed in several structures, including adult head; adult heart; larval muscle system; muscle cell; and spermatozoon. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to several human genes including PFKL (phosphofructokinase, liver type) and PFKM (phosphofructokinase, muscle).
FB Description
Phosphofructokinase (Pfk) encodes an enzyme that catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate. It is involved in the first committed step of glycolysis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13697
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pfk molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Pfk role
            Pfk genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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