Gene

Egfr

Species
Drosophila melanogaster
Symbol
Egfr
Name
Epidermal growth factor receptor
Synonyms
  • C-erb
  • c-erbB
Biotype
protein coding gene
Automated Description
Enables epidermal growth factor receptor activity. Involved in several processes, including compound eye morphogenesis; open tracheal system development; and regionalization. Located in plasma membrane. Is active in apical plasma membrane. Colocalizes with cytoneme. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; epithelium; gut section; and imaginal disc. Used to study alcohol use disorder; carcinoma; cardiomyopathy; and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including ERBB4 (erb-b2 receptor tyrosine kinase 4).
FB Description
Epidermal growth factor receptor (Egfr) encodes the transmembrane tyrosine kinase receptor for signaling ligands (encoded by grk, spi, vn, and Krn) in the TGFalpha family, which utilises the intracellular MAP kinase pathway. The product of Egfr contributes to growth regulation, cell survival and developmental patterning.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
21.525M21.530M21.535M21.540M21.545M21.550M21.555M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions