Enables epidermal growth factor receptor activity. Involved in several processes, including compound eye morphogenesis; open tracheal system development; and regionalization. Located in plasma membrane. Is active in apical plasma membrane. Colocalizes with cytoneme. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; epithelium; gut section; and imaginal disc. Used to study alcohol use disorder; carcinoma; cardiomyopathy; and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including ERBB4 (erb-b2 receptor tyrosine kinase 4).
FB Description
Epidermal growth factor receptor (Egfr) encodes the transmembrane tyrosine kinase receptor for signaling ligands (encoded by grk, spi, vn, and Krn) in the TGFalpha family, which utilises the intracellular MAP kinase pathway. The product of Egfr contributes to growth regulation, cell survival and developmental patterning.