Version: 8.0.0Date: Tue Jan 28 2025
Gene
Egfr
- Species
- Drosophila melanogaster
- Symbol
- Egfr
- Name
- Epidermal growth factor receptor
- Synonyms
- C-erb
- c-erbB
- Biotype
- protein coding gene
- Automated Description
- Enables epidermal growth factor receptor activity. Involved in several processes, including compound eye morphogenesis; open tracheal system development; and regionalization. Located in plasma membrane. Is active in apical plasma membrane. Colocalizes with cytoneme. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; epithelium; gut section; and imaginal disc. Used to study alcohol use disorder; carcinoma; cardiomyopathy; and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including ERBB4 (erb-b2 receptor tyrosine kinase 4).
- FB Description
- Epidermal growth factor receptor (Egfr) encodes the transmembrane tyrosine kinase receptor for signaling ligands (encoded by grk, spi, vn, and Krn) in the TGFalpha family, which utilises the intracellular MAP kinase pathway. The product of Egfr contributes to growth regulation, cell survival and developmental patterning.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24416
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr2R:21522420...21559977 + (37.56 kb)
- Assembly version
- R6
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.