Version: 8.0.0
Date: Tue Jan 28 2025
porin
Drosophila melanogasterFB:FBgn0004363
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

porin

Species
Drosophila melanogaster
Symbol
porin
Name
porin
Synonyms
  • anon-WO02059370.56
  • CG6647
Biotype
protein coding gene
Automated Description
Enables voltage-gated monoatomic anion channel activity. Involved in several processes, including negative regulation of calcium import into the mitochondrion; sperm individualization; and sperm mitochondrion organization. Located in Nebenkern and mitochondrion. Is active in mitochondrial outer membrane. Is expressed in several structures, including embryonic/larval midgut primordium; follicle cell; gonad; head epidermis primordium; and trunk visceral muscle primordium. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including VDAC1 (voltage dependent anion channel 1) and VDAC2 (voltage dependent anion channel 2).
FB Description
porin (porin) encodes a beta-barrel channel protein localized in the outer membrane of mitochondria that conducts translocation of various ions and metabolites between cytoplasm and mitochondria. It plays roles in mitochondria dynamics and mitophagy, and is ubiquitinated by the E3 ligases encoded by park and Mul1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11743
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          porin molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            porin role
            porin genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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