Version: 8.0.0
Date: Tue Jan 28 2025
drk
Drosophila melanogasterFB:FBgn0004638
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

drk

Species
Drosophila melanogaster
Symbol
drk
Name
downstream of receptor kinase
Synonyms
  • 24/1
  • CG6033
Biotype
protein coding gene
Automated Description
Enables phosphotyrosine residue binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; learning or memory; and open tracheal system development. Located in plasma membrane and presynapse. Part of protein-containing complex. Is expressed in several structures, including embryonic/larval midgut primordium; imaginal disc; somatic trunk mesoderm derivative; synaptic neuropil domain; and synaptic neuropil subdomain. Used to study autosomal recessive nonsyndromic deafness 114. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114; breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to several human genes including GRB2 (growth factor receptor bound protein 2).
FB Description
downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46037
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          drk molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            drk role
            drk genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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