Version: 8.0.0
Date: Tue Jan 28 2025
ci
Drosophila melanogasterFB:FBgn0004859
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ci

Species
Drosophila melanogaster
Symbol
ci
Name
cubitus interruptus
Synonyms
  • Ce
  • Cell
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of hippo signaling; regionalization; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of Hedgehog signaling complex. Is expressed in several structures, including anlage in statu nascendi; developmental compartment; germ layer; head epidermis primordium; and imaginal disc. Used to study primary bacterial infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Culler-Jones syndrome; Pallister-Hall syndrome; anodontia; polydactyly (multiple); and synostosis (multiple). Orthologous to several human genes including GLI2 (GLI family zinc finger 2) and GLI3 (GLI family zinc finger 3).
FB Description
cubitus interruptus (ci) encodes a Zn-finger family of transcription factor. It contributes to Hedgehog (Hh) signaling pathway that is involved in pattern formation and growth control. The product of ci undergoes limited proteolysis to be converted into a truncated form that function as a transcription repressor in the absence of the ligand encoded by hh but is converted into a full-length transcription activator in the presence of the product of hh.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45718
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ci molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              ci role
              ci genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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