Gene

ph-p

Species
Drosophila melanogaster
Symbol
ph-p
Name
polyhomeotic proximal
Synonyms
  • CG18412
  • CG18414
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA topoisomerase binding activity; chromatin binding activity; and protein-folding chaperone binding activity. Involved in several processes, including follicle cell of egg chamber development; regulation of gene expression; and syncytial blastoderm mitotic cell cycle. Located in nucleolus and polytene chromosome. Part of PRC1 complex. Is expressed in several structures, including epithelium; germline cell; imaginal disc; presumptive embryonic/larval system; and synaptic neuropil subdomain. Used to study cancer. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 11. Orthologous to several human genes including PHC1 (polyhomeotic homolog 1) and PHC3 (polyhomeotic homolog 3).
FB Description
polyhomeotic proximal (ph-p) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-d, ph-p functions as a tumor suppressor gene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12247
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
2.128M2.130M2.132M2.134M2.136M2.138M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions