Version: 8.0.0
Date: Tue Jan 28 2025
phtm
Drosophila melanogasterFB:FBgn0004959
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

phtm

Species
Drosophila melanogaster
Symbol
phtm
Name
phantom
Synonyms
  • 306a1
  • CG6578
Biotype
protein coding gene
Automated Description
Enables ecdysteroid 25-hydroxylase activity. Involved in border follicle cell migration; ecdysone biosynthetic process; and embryonic development via the syncytial blastoderm. Located in endoplasmic reticulum. Is expressed in several structures, including antennal anlage; antennal primordium; epithelium; head epidermis primordium; and neurohemal organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); drug dependence (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including CYP2R1 (cytochrome P450 family 2 subfamily R member 1).
FB Description
phantom (phtm) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It is an endoplasmic reticulum protein that catalyzes the addition of a hydroxyl group to the 25 carbon of the cholesterol side chain. phtm mutants fail to undergo head involution, dorsal closure and cuticle secretion.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24300
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            18.6860M18.6865M18.6870M18.6875M18.6880M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            phtm molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              phtm role
              phtm genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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