Version: 8.0.0
Date: Tue Jan 28 2025
Jheh1
Drosophila melanogasterFB:FBgn0010053
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Jheh1

Species
Drosophila melanogaster
Symbol
Jheh1
Name
Juvenile hormone epoxide hydrolase 1
Synonyms
  • 142196_at
  • BEST:GH06241
Biotype
protein coding gene
Automated Description
Enables juvenile hormone epoxide hydrolase activity. Involved in juvenile hormone catabolic process. Is expressed in adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut; and fat body/gonad primordium. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1).
FB Description
Juvenile hormone epoxide hydrolase 1 (Jheh1) expression changes are associated with increased tolerance to oxidative stress.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21661
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensEPHX18 of 9YesNo☑ ☑☑☑☑☑☑☐☑  
Mus musculusEphx19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Rattus norvegicusEphx19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisephx17 of 9YesNo☑ ☑☑☑☐☑☑☑☐  
Danio rerioephx19 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☐
Danio rerioephx54 of 10NoYes☑ ☐☐☐☑☑☐☑☐ ☐
Caenorhabditis elegansW01A11.17 of 9YesNo☐ ☑☑☑☑☑☑☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Jheh2145969557 of 8☑ ☑☐☑☑☑☑☑ 
Jheh3246568527 of 8☑ ☑☐☑☑☑☑☑ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
fertile
viable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    R6
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Jheh1d08367
    • Jheh1[d08367]
    		allele with one associated variant
    insertion
    • non coding transcript exon variant
    		Yes
    NT_033778.4:g.18854903C>Tvariant
    SNP
    • 5 prime UTR variant
    NT_033778.4:g.18854972C>Tvariant
    SNP
    • 5 prime UTR variant
    NT_033778.4:g.18854898G>Tvariant
    SNP
    • 5 prime UTR variant
    NT_033778.4:g.18855032G>Cvariant
    SNP
    • 5 prime UTR variant
    NT_033778.4:g.18853647A>Tvariant
    SNP
    • synonymous variant
    NT_033778.4:g.18853683A>Cvariant
    SNP
    • missense variant
    NT_033778.4:g.18853797T>Cvariant
    SNP
    • synonymous variant
    NT_033778.4:g.18854298A>Gvariant
    SNP
    • intron variant
    NT_033778.4:g.18853671G>Cvariant
    SNP
    • synonymous variant
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    Species
    (carrying the transgene)
    Allele symbol
    Transgenic construct
    Expressed components
    Knock-down targets
    Regulatory regions
    Has Disease Annotations
    Has Phenotype Annotations
    Drosophila melanogasterJheh1GD501
    P{GD501}
    • UASt
    Drosophila melanogasterJheh1HMC03077
    P{TRiP.HMC03077}
    • UAS
    Drosophila melanogasterJheh1KK112665
    P{KK112665}
    • UASt
    Drosophila melanogasterJheh1TKO.GS00605
    P{TKO.GS00605}
    Drosophila melanogasterJheh1TOE.GS01872
    P{TOE.GS01872}
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    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    R6
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    2 interactor genes based on 3 annotations
    Jheh1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Argk2Drosophila melanogaster
    protein
    • two hybrid
    		PMID:14605208
    protein
    		sturkopfDrosophila melanogaster
    protein
    • split luciferase complementation
    		PMID:30917324
    protein
    		sturkopfDrosophila melanogaster
    protein
    • anti tag coimmunoprecipitation
    		PMID:30917324
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    Genetic Interactions

    No data available