Gene

dap

Species
Drosophila melanogaster
Symbol
dap
Name
dacapo
Synonyms
  • CDI4
  • cdi4
Biotype
protein coding gene
Automated Description
Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including germarium-derived oocyte fate determination; negative regulation of mitotic cell cycle; and sensory organ precursor cell division. Located in nucleus. Is expressed in several structures, including endoderm anlage; epithelium; ganglia; germline cell; and larval optic anlage. Human ortholog(s) of this gene implicated in several diseases, including Beckwith-Wiedemann syndrome; IMAGe syndrome; hematologic cancer (multiple); hyperinsulinism; and multiple endocrine neoplasia type 4. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B) and CDKN1C (cyclin dependent kinase inhibitor 1C).
FB Description
dacapo (dap) encodes a Cyclin-dependent kinase inhibitor in the CIP/KIP family. It binds to CycE-Cdk2 complexes and thereby inhibits their protein kinase activity. Upregulation of dap is required after the last mitosis for arresting cells in G1/G0 before terminal differentiation in many post-mitotic cell types.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10265
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal mitotic cell cycle
abnormal neuroanatomy
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage | recessive
apterous-expressing neuron of the lateral cluster of the thorax Ap4 | increased number
apterous-expressing neuron of the lateral cluster of the thorax | ectopic
decreased occurrence of cell division
embryo
embryonic abdomen & glial cell | ectopic
embryonic epidermis
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Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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9.7125M9.7130M9.7135M9.7140M9.7145M9.7150M9.7155M9.7160M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions