Gene

Dif

Species
Drosophila melanogaster
Symbol
Dif
Name
Dorsal-related immunity factor
Synonyms
  • 6794
  • CG6794
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Toll signaling pathway; defense response to other organism; and positive regulation of macromolecule biosynthetic process. Located in cytosol and nucleus. Is expressed in adult heart; embryonic/larval fat body; embryonic/larval posterior spiracle; and embryonic/larval salivary gland. Used to study bacterial infectious disease. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); ductal carcinoma in situ; immunodeficiency 53; and lymphoma. Orthologous to several human genes including RELA (RELA proto-oncogene, NF-kB subunit).
FB Description
Dorsal-related immunity factor (Dif) encodes a transcription factor that contributes to zygotic function of the Toll pathway, notably the regulation of antimicrobial peptides, but it is not involved in dorsoventral patterning of the embryo.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24169
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Dif molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Dif role
            Dif genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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