Version: 8.0.0
Date: Tue Jan 28 2025
Fer1HCH
Drosophila melanogasterFB:FBgn0015222
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Fer1HCH

Species
Drosophila melanogaster
Symbol
Fer1HCH
Name
Ferritin 1 heavy chain homologue
Synonyms
  • 1HCH
  • BEST:LD36673
Biotype
protein coding gene
Automated Description
Enables ferrous iron binding activity. Involved in several processes, including detoxification of iron ion; iron ion import across plasma membrane; and sleep. Located in Golgi apparatus and fusome. Part of ferritin complex. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; epithelial cell; nephrocyte; and somatic trunk mesoderm derivative.
FB Description
Ferritin 1 heavy chain homologue (Fer1HCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer1HCH has ferroxidase activity required for iron loading into ferritin and is essential for embryogenesis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11431
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Fer1HCH molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            Fer1HCH role
            Fer1HCH genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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