Version: 8.0.0
Date: Tue Jan 28 2025
Pi3K92E
Drosophila melanogasterFB:FBgn0015279
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pi3K92E

Species
Drosophila melanogaster
Symbol
Pi3K92E
Name
Phosphatidylinositol 3-kinase 92E
Synonyms
  • anon-92Ed
  • CG4141
Biotype
protein coding gene
Automated Description
Enables 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity; and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of developmental growth; and positive regulation of hemocyte differentiation. Part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in adult head; organism; and ventral furrow. Used to study alcohol use disorder; cancer (multiple); glucose metabolism disease (multiple); and heart disease. Human ortholog(s) of this gene implicated in colorectal cancer; glioblastoma; immunodeficiency 14; reproductive organ cancer (multiple); and schizophrenia. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) and PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta).
FB Description
Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10048
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pi3K92E molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            Pi3K92E role
            Pi3K92E genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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