Enables AP-2 adaptor complex binding activity and PTB domain binding activity. Involved in several processes, including dendrite morphogenesis; positive regulation of Notch signaling pathway; and regulation of clathrin-dependent endocytosis. Located in axon; dendrite; and neuronal cell body. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; embryonic/larval midgut; gland; and nephrocyte. Orthologous to several human genes including AAK1 (AP2 associated kinase 1).
FB Description
Numb-associated kinase (Nak) encodes an Ark family member that regulates the product of numb function. It contributes to dendrite development by regulating clathrin localization.