Gene

Nak

Species
Drosophila melanogaster
Symbol
Nak
Name
Numb-associated kinase
Synonyms
  • CG10637
  • nak
Biotype
protein coding gene
Automated Description
Enables AP-2 adaptor complex binding activity and PTB domain binding activity. Involved in several processes, including dendrite morphogenesis; positive regulation of Notch signaling pathway; and regulation of clathrin-dependent endocytosis. Located in axon; dendrite; and neuronal cell body. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; embryonic/larval midgut; gland; and nephrocyte. Orthologous to several human genes including AAK1 (AP2 associated kinase 1).
FB Description
Numb-associated kinase (Nak) encodes an Ark family member that regulates the product of numb function. It contributes to dendrite development by regulating clathrin localization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22967
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
18.958M18.959M18.960M18.961M18.962M18.963M18.964M18.965M18.966M18.967M18.968M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions