Leucine-rich repeat-containing G protein-coupled receptor 1
Synonyms
CG7665
DLGR-1
Biotype
protein coding gene
Automated Description
Enables G protein-coupled receptor activity; hormone binding activity; and protein-hormone receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in anal pad primordium; embryonic anal pad; embryonic proventriculus inner layer; gut section; and rectum primordium. Human ortholog(s) of this gene implicated in several diseases, including Leydig cell tumor; autoimmune disease (multiple); familial male-limited precocious puberty; gonadal disease (multiple); and hyperthyroidism (multiple). Orthologous to human FSHR (follicle stimulating hormone receptor); LHCGR (luteinizing hormone/choriogonadotropin receptor); and TSHR (thyroid stimulating hormone receptor).
FB Description
Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors.