Gene

Lgr1

Species
Drosophila melanogaster
Symbol
Lgr1
Name
Leucine-rich repeat-containing G protein-coupled receptor 1
Synonyms
  • CG7665
  • DLGR-1
Biotype
protein coding gene
Automated Description
Enables G protein-coupled receptor activity; hormone binding activity; and protein-hormone receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in anal pad primordium; embryonic anal pad; embryonic proventriculus inner layer; gut section; and rectum primordium. Human ortholog(s) of this gene implicated in several diseases, including Leydig cell tumor; autoimmune disease (multiple); familial male-limited precocious puberty; gonadal disease (multiple); and hyperthyroidism (multiple). Orthologous to human FSHR (follicle stimulating hormone receptor); LHCGR (luteinizing hormone/choriogonadotropin receptor); and TSHR (thyroid stimulating hormone receptor).
FB Description
Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24372
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
17.726M17.727M17.728M17.729M17.730M17.731M17.732M17.733M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions