Gene

Stat92E

Species
Drosophila melanogaster
Symbol
Stat92E
Name
Signal-transducer and activator of transcription protein at 92E
Synonyms
  • CG4257
  • d-STAT
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone binding activity. Involved in several processes, including larval development; oogenesis; and regionalization. Located in cytoplasmic side of apical plasma membrane; cytosol; and nucleus. Is expressed in several structures, including follicle cell; germline cell; gut section; head epidermis primordium; and somatic cell of testis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); reproductive organ cancer (multiple); and scleroderma (multiple). Orthologous to several human genes including STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B).
FB Description
Signal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11801
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            20.536M20.538M20.540M20.542M20.544M20.546M20.548M20.550M20.552M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Stat92E molecule type
            Interactor gene
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              Genetic Interactions

              Stat92E role
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