Gene

Ork1

Species
Drosophila melanogaster
Symbol
Ork1
Name
Open rectifier K[+] channel 1
Synonyms
  • anon-WO0161006.1
  • anon-WO0161006.22
Biotype
protein coding gene
Automated Description
Enables potassium ion leak channel activity and protein homodimerization activity. Involved in locomotor rhythm; potassium ion transmembrane transport; and regulation of heart rate. Located in membrane. Part of potassium channel complex. Is expressed in several structures, including adult brain; adult head; adult muscle system; embryonic/larval heart; and ovary. Used to study heart conduction disease. Orthologous to several human genes including KCNK10 (potassium two pore domain channel subfamily K member 10).
FB Description
Open rectifier K[+] channel 1 (Ork1) encodes a member of the two pore open rectifier potassium channel gene family. It contributes to the regulation of membrane resting potential. The primary gating mechanism for the product of Ork1 appears to be based on phosphorylation of multiple serine, threonine and tyrosine residues in the large intracellular C-terminal tail.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11003
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
10.880M10.882M10.884M10.886M10.888M10.890M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions