Enables potassium ion leak channel activity and protein homodimerization activity. Involved in locomotor rhythm; potassium ion transmembrane transport; and regulation of heart rate. Located in membrane. Part of potassium channel complex. Is expressed in several structures, including adult brain; adult head; adult muscle system; embryonic/larval heart; and ovary. Used to study heart conduction disease. Orthologous to several human genes including KCNK10 (potassium two pore domain channel subfamily K member 10).
FB Description
Open rectifier K[+] channel 1 (Ork1) encodes a member of the two pore open rectifier potassium channel gene family. It contributes to the regulation of membrane resting potential. The primary gating mechanism for the product of Ork1 appears to be based on phosphorylation of multiple serine, threonine and tyrosine residues in the large intracellular C-terminal tail.