Version: 8.0.0
Date: Tue Jan 28 2025
Fak
Drosophila melanogasterFB:FBgn0020440
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Fak

Species
Drosophila melanogaster
Symbol
Fak
Name
Focal adhesion kinase
Synonyms
  • CG10023
  • CT28129
Biotype
protein coding gene
Automated Description
Enables non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of receptor recycling and negative regulation of synaptic assembly at neuromuscular junction. Located in focal adhesion; type Ib terminal bouton; and type Is terminal bouton. Is expressed in several structures, including brain; cephalic furrow; egg chamber; follicle cell; and midgut primordium. Human ortholog(s) of this gene implicated in breast cancer; hypertension; leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to several human genes including PTK2 (protein tyrosine kinase 2).
FB Description
Focal adhesion kinase (Fak) encodes a non-Receptor Tyrosine kinase (nRTK) that is involved in signaling and cytoskeletal dynamics integrating signals from RTKs and integrins. Its function has been described in multiple contexts including embryonic muscle attachement, morphogensis of the optic stalk, synaptic growth and transmission, and in the regulation of RTK-MAP kinase signaling in epithelia.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46221
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Fak molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Fak role
            Fak genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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