Version: 8.0.0
Date: Tue Jan 28 2025
Pi3K21B
Drosophila melanogasterFB:FBgn0020622
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pi3K21B

Species
Drosophila melanogaster
Symbol
Pi3K21B
Name
Pi3K21B
Synonyms
  • CG2699
  • deltap60
Biotype
protein coding gene
Automated Description
Enables kinase binding activity and phosphotyrosine residue binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of feeding behavior; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval midgut; embryonic/larval midgut primordium; germline cell; and pole plasm. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; carcinoma (multiple); endometrial cancer (multiple); and immunodeficiency 36. Orthologous to several human genes including PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3).
FB Description
Pi3K21B (Pi3K21B) encodes an adaptor protein (p60) that binds the product of Pi3K92E to form the functional class IA phosphoinositide 3-kinase. This heterodimeric kinase is involved in phosphatidylinositol phosphorylation and regulates cell size and proliferation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10155
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pi3K21B molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Pi3K21B role
            Pi3K21B genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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