Gene

Mnt

Species
Drosophila melanogaster
Symbol
Mnt
Name
Mnt
Synonyms
  • bHLHe43
  • CG13316
Biotype
protein coding gene
Automated Description
Enables protein heterodimerization activity and sequence-specific DNA binding activity. Involved in negative regulation of cell growth; negative regulation of transcription by RNA polymerase II; and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including epithelium; ganglia; head epidermis primordium; imaginal disc; and presumptive embryonic/larval system. Orthologous to human MNT (MAX network transcriptional repressor).
FB Description
Mnt (Mnt) encodes a protein that belongs to the basic-helic-loop-helix-zipper class of transcription factors, which form heterodimers with the protein encoded by Max. Mnt product acts as a repressor of transcription by recruiting a co-repressor complex to its genomic binding sites. It antagonizes cell growth promoting functions of the product encoded by Myc and its depletion produces flies with larger cells, increased weight, and decreased lifespan.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11969
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
3.675M3.680M3.685M3.690M3.695M3.700M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions