Version: 8.0.0
Date: Tue Jan 28 2025
Dap160
Drosophila melanogasterFB:FBgn0023388
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Dap160

Species
Drosophila melanogaster
Symbol
Dap160
Name
Dynamin associated protein 160
Synonyms
  • CG1099
  • DAP-160
Biotype
protein coding gene
Automated Description
Enables protein kinase activator activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of neuroblast proliferation; and synaptic vesicle endocytosis. Located in apical cortex and synaptic vesicle. Colocalizes with presynaptic membrane. Is expressed in several structures, including adult heart; embryonic foregut sensory structure; embryonic head epidermis; ganglia; and head. Used to study intellectual disability. Orthologous to several human genes including ITSN2 (intersectin 2).
FB Description
Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11216
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Dap160 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Dap160 role
            Dap160 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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