Predicted to enable MAP kinase kinase activity. Involved in several processes, including JNK cascade; regulation of adult chitin-containing cuticle pigmentation; and tumor necrosis factor-mediated signaling pathway. Located in axon. Is expressed in several structures, including adult head; adult mushroom body; anterior endoderm; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4).
FB Description
MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability.