Gene

Mkk4

Species
Drosophila melanogaster
Symbol
Mkk4
Name
MAP kinase kinase 4
Synonyms
  • 142758_at
  • CG9738
Biotype
protein coding gene
Automated Description
Predicted to enable MAP kinase kinase activity. Involved in several processes, including JNK cascade; regulation of adult chitin-containing cuticle pigmentation; and tumor necrosis factor-mediated signaling pathway. Located in axon. Is expressed in several structures, including adult head; adult mushroom body; anterior endoderm; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4).
FB Description
MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48013
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
8.6465M8.6470M8.6475M8.6480M8.6485M8.6490M8.6495M8.6500M8.6505M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions