Version: 8.0.0
Date: Tue Jan 28 2025
par-6
Drosophila melanogasterFB:FBgn0026192
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

par-6

Species
Drosophila melanogaster
Symbol
par-6
Name
par-6
Synonyms
  • CG5884
  • Dm-Par-6
Biotype
protein coding gene
Automated Description
Enables protein kinase inhibitor activity. Involved in several processes, including border follicle cell migration; nervous system development; and positive regulation of plasma membrane bounded cell projection assembly. Located in several cellular components, including apical cortex; apical plasma membrane; and muscle cell postsynaptic specialization. Part of PAR polarity complex. Is expressed in several structures, including adult head; embryonic hindgut; epithelial cell; epithelium; and germarium region 2. Orthologous to several human genes including PARD6B (par-6 family cell polarity regulator beta) and PARD6G (par-6 family cell polarity regulator gamma).
FB Description
par-6 (par-6) encodes a scaffold protein that forms a complex with the products of baz and aPKC and with other cortical, cytoskeletal and regulatory proteins. It is involved in cell polarization, actin-based protrusion formation and tracheal branching.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14102
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          par-6 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            par-6 role
            par-6 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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