Involved in several processes, including dorsal appendage formation; germ cell migration; and regionalization. Located in several cellular components, including cell cortex; perinuclear region of cytoplasm; and pole plasm. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in germarium; nurse cell; oocyte; organism; and ovary. Orthologous to human SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) and SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4).
FB Description
gustavus (gus) encodes a cullin-RING ubiquitin E3 ligase specificity receptor. It interacts genetically and physically with the product of Cul5, and putatively regulates stability of target proteins including the one encoded by vas. It is involved in oogenesis and germ cell maintenance.