Version: 8.0.0
Date: Tue Jan 28 2025
PAPLA1
Drosophila melanogasterFB:FBgn0031990
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

PAPLA1

Species
Drosophila melanogaster
Symbol
PAPLA1
Name
Phosphatidic Acid Phospholipase A1
Synonyms
  • CG14278
  • CG8552
Biotype
protein coding gene
Automated Description
Enables phospholipase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; rhodopsin biosynthetic process; and spermatogenesis. Located in COPII-coated ER to Golgi transport vesicle. Is expressed in several structures, including adult brain cell body rind; adult head; germline cell; gland; and gut section. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 54. Orthologous to human DDHD2 (DDHD domain containing 2) and SEC23IP (SEC23 interacting protein).
FB Description
Phosphatidic Acid Phospholipase A1 (PAPLA1) encodes a protein required for the endoplasmic reticulum to Golgi trafficking of a family of G-protein coupled receptors.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23509
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          PAPLA1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            PAPLA1 role
            PAPLA1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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