Version: 8.0.0
Date: Tue Jan 28 2025
Sfmbt
Drosophila melanogasterFB:FBgn0032475
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Sfmbt

Species
Drosophila melanogaster
Symbol
Sfmbt
Name
Scm-related gene containing four mbt domains
Synonyms
  • CG16975
  • dSFMBT
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity and methylated histone binding activity. Involved in heterochromatin formation; imaginal disc growth; and oogenesis. Located in nucleus. Part of PcG protein complex. Is expressed in several structures, including embryonic central brain neurons; embryonic/larval midgut; ganglia; larval nervous system; and ventral ectoderm. Orthologous to human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1).
FB Description
Scm-related gene containing four mbt domains (Sfmbt) encodes a subunit of the Polycomb Group protein complex Pho repressive complex (PhoRC). This chromatin binding protein recognizes with high selectivity mono- and dimethylated lysine residues in various histone peptides.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12247
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Sfmbt molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Sfmbt role
            Sfmbt genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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