Version: 8.0.0
Date: Tue Jan 28 2025
nrv3
Drosophila melanogasterFB:FBgn0032946
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

nrv3

Species
Drosophila melanogaster
Symbol
nrv3
Name
nervana 3
Synonyms
  • CG8663
  • JYbeta1
Biotype
protein coding gene
Automated Description
Predicted to enable ATPase activator activity. Involved in response to auditory stimulus and sensory perception of sound. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; embryonic central brain neurons; embryonic head sensory system; and ventral nerve cord. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to several human genes including ATP1B4 (ATPase Na+/K+ transporting family member beta 4); ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); and ATP1B2 (ATPase Na+/K+ transporting subunit beta 2).
FB Description
nervana 3 (nrv3) encodes one of three beta subunits of the sodium-potassium pump (ATPalpha). nrv3 is expressed in the nervous system, including subsets of the CNS and Johnston's organ neurons, and is required for hearing.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11523
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            21.380M21.382M21.384M21.386M21.388M21.390M21.392M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nrv3 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              nrv3 role
              nrv3 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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