Version: 8.0.0
Date: Tue Jan 28 2025
DopEcR
Drosophila melanogasterFB:FBgn0035538
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

DopEcR

Species
Drosophila melanogaster
Symbol
DopEcR
Name
Dopamine/Ecdysteroid receptor
Synonyms
  • anon-WO0170980.139
  • anon-WO0170980.140
Biotype
protein coding gene
Automated Description
Enables dopamine neurotransmitter receptor activity, coupled via Gs and ecdysone binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to sucrose stimulus; and learning. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe; adult brain; adult head; adult mushroom body; and ganglia. Used to study alcohol use disorder and renal fibrosis. Orthologous to human GPR21 (G protein-coupled receptor 21) and GPR52 (G protein-coupled receptor 52).
FB Description
Dopamine/Ecdysteroid receptor (DopEcR) encodes a GPCR that shows ligand-biased activation. It can be activated by dopamine to increase cyclic AMP levels and by the insect steroid ecdysone to activate the MAPKinase pathway. It is widely expressed in the nervous system and can modulate a wide variety of complex behaviors including male courtship, locomotion, the response to stressful social interactions and the regulation of appetite.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24248
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

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    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          DopEcR molecule type
          Interactor gene
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            Genetic Interactions

            DopEcR role
            DopEcR genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
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