Version: 8.0.0
Date: Tue Jan 28 2025
srl
Drosophila melanogasterFB:FBgn0037248
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

srl

Species
Drosophila melanogaster
Symbol
srl
Name
spargel
Synonyms
  • CG 9809
  • cg9809
Biotype
protein coding gene
Automated Description
Predicted to enable mRNA binding activity and nuclear receptor coactivator activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of insulin receptor signaling pathway; and positive regulation of metabolic process. Located in cytosol and nuclear speck. Is expressed in several structures, including adult gnathal ganglion; anterior endoderm; embryonic/larval midgut primordium; fat body; and larval somatic muscle cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); obesity; and type 2 diabetes mellitus. Orthologous to several human genes including PPARGC1A (PPARG coactivator 1 alpha) and PPRC1 (PPARG related coactivator 1).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15528
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            4.423M4.424M4.425M4.426M4.427M4.428M4.429M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            srl molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              srl role
              srl genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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