Version: 8.0.0
Date: Tue Jan 28 2025
wkd
Drosophila melanogasterFB:FBgn0037917
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

wkd

Species
Drosophila melanogaster
Symbol
wkd
Name
whacked
Synonyms
  • cg5344
  • CG5344
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activator activity. Involved in lumen formation, open tracheal system and polarity specification of proximal/distal axis. Located in cytoplasm; cytoplasmic side of apical plasma membrane; and filopodium. Is expressed in embryonic head epidermis; embryonic hindgut; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to several human genes including TBC1D10A (TBC1 domain family member 10A) and TBC1D10C (TBC1 domain family member 10C).
FB Description
whacked (wkd) encodes a RabGAP that catalyzes the GTPase activity of its Rab-GTP partners. Its essential substrate appears to be the product of Rab35. wkd mutations are associated with seamless tube defects in the tracheal system.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22957
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            11.5820M11.5825M11.5830M11.5835M11.5840M11.5845M11.5850M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            wkd molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              wkd role
              wkd genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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