Version: 8.0.0
Date: Tue Jan 28 2025
Asap
Drosophila melanogasterFB:FBgn0050372
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Asap

Species
Drosophila melanogaster
Symbol
Asap
Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain
Synonyms
  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
  • ASAP
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activator activity and phosphatidylinositol phosphate binding activity. Involved in several processes, including compound eye morphogenesis; mitotic cleavage furrow ingression; and regulation of Golgi organization. Located in apical part of cell and cytoplasm. Colocalizes with adherens junction; nucleus; and plasma membrane. Is expressed in adult head. Orthologous to several human genes including ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1).
FB Description
ArfGAP with SH3 domain, ankyrin repeat and PH domain (Asap) encodes a GTPase activating proteins for Arf family GTPases. Arf proteins regulate actin dynamics, cell shape, and cell positioning within epithelia such as the eye.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45854
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Asap molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Asap role
            Asap genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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