Gene

Mer

Species
Drosophila melanogaster
Symbol
Mer
Name
Merlin
Synonyms
  • BG01543
  • CG14228
Biotype
protein coding gene
Automated Description
Enables protein-membrane adaptor activity. Involved in several processes, including R8 cell differentiation; germ cell development; and meiotic nuclear division. Located in several cellular components, including Nebenkern; apicomedial cortex; and subapical part of cell. Part of Kibra-Ex-Mer complex. Is active in cytoplasmic side of apical plasma membrane. Colocalizes with cell-cell junction. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor).
FB Description
Merlin (Mer) encodes a FERM domain containing protein that promotes assembly of a functional Hippo signaling complex at the apical cell cortex. It has also been associated with cell junctions and endocytic compartments.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23281
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
19.6900M19.6905M19.6910M19.6915M19.6920M19.6925M19.6930M19.6935M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions