Version: 8.0.0
Date: Tue Jan 28 2025
5-HT2A
Drosophila melanogasterFB:FBgn0087012
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

5-HT2A

Species
Drosophila melanogaster
Symbol
5-HT2A
Name
5-hydroxytryptamine (serotonin) receptor 2A
Synonyms
  • 5-HT
  • 5-HT-2a
Biotype
protein coding gene
Automated Description
Enables G protein-coupled serotonin receptor activity. Involved in germ-band extension; positive regulation of feeding behavior; and serotonin receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including adult protocerebrum; dorsal ectoderm; dorsal ectoderm anlage; ganglia; and large field neurons. Used to study generalized anxiety disorder. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B).
FB Description
5-hydroxytryptamine (serotonin) receptor 2A (5-HT2A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24247
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            4.614M4.616M4.618M4.620M4.622M4.624M4.626M4.628M4.630M4.632M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            5-HT2A molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              5-HT2A role
              5-HT2A genetic perturbation
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