Version: 8.0.0
Date: Tue Jan 28 2025
glo
Drosophila melanogasterFB:FBgn0259139
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

glo

Species
Drosophila melanogaster
Symbol
glo
Name
glorund
Synonyms
  • 110/46
  • anon-WO0118547.328
Biotype
protein coding gene
Automated Description
Predicted to enable mRNA binding activity. Involved in chromosome organization; oocyte axis specification; and regulation of translation. Part of protein-containing complex. Is expressed in adult head; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in Sjogren's syndrome and syndromic X-linked intellectual developmental disorder bain type. Orthologous to several human genes including HNRNPF (heterogeneous nuclear ribonucleoprotein F) and HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2).
FB Description
glorund (glo) encodes a hnRNP F/H family RNA-binding protein that binds directly to nanos mRNA and regulates its translation during late stages of oogenesis. The functions of the product of glo include nurse cell nuclear chromatin organization, axis patterning as well as being required for viability to adulthood.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13976
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          glo molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            glo role
            glo genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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