Version: 8.0.0
Date: Tue Jan 28 2025
Pp2A-29B
Drosophila melanogasterFB:FBgn0260439
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pp2A-29B

Species
Drosophila melanogaster
Symbol
Pp2A-29B
Name
Protein phosphatase 2A at 29B
Synonyms
  • 29B
  • 65 kDa regulatory subunit of protein phosphatase
Biotype
protein coding gene
Automated Description
Predicted to enable protein phosphatase regulator activity. Involved in several processes, including membraneless organelle assembly; receptor guanylyl cyclase signaling pathway; and regulation of signal transduction. Located in centriole and cytosol. Part of FAR/SIN/STRIPAK complex. Is active in nucleus. Is expressed in several structures, including adult head; adult midgut; brain; embryonic/larval salivary gland; and female germline cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36 and lung cancer. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha) and PPP2R1B (protein phosphatase 2 scaffold subunit Abeta).
FB Description
Protein phosphatase 2A at 29B (Pp2A-29B) encodes the structural A subunit of the trimeric PP2A phosphatase enzyme. It links the catalytic C subunit encoded by mts and a variable regulatory B family subunit, which directs the enzyme to distinct substrates. The roles of Pp2A-29B product include centriole duplication, chromosome segregation, autophagy, axonal transport, growth regulation, and active zone stabilization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10648
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    No data available

    Alleles and Variants

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    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pp2A-29B molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            Pp2A-29B role
            Pp2A-29B genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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