Version: 8.0.0
Date: Tue Jan 28 2025
GABA-B-R1
Drosophila melanogasterFB:FBgn0260446
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

GABA-B-R1

Species
Drosophila melanogaster
Symbol
GABA-B-R1
Name
metabotropic GABA-B receptor subtype 1
Synonyms
  • anon-WO0170980.175
  • anon-WO0170980.176
Biotype
protein coding gene
Automated Description
Enables G protein-coupled GABA receptor activity and protein heterodimerization activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and gamma-aminobutyric acid signaling pathway. Located in plasma membrane. Part of G protein-coupled receptor heterodimeric complex. Is expressed in adult head; larval brain; larval central nervous system; larval gnathal ganglion; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1).
FB Description
metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10519
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          GABA-B-R1 molecule type
          Interactor gene
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            Genetic Interactions

            GABA-B-R1 role
            GABA-B-R1 genetic perturbation
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            Interactor genetic perturbation
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            Phenotype or trait
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