Version: 8.0.0
Date: Tue Jan 28 2025
Diap1
Drosophila melanogasterFB:FBgn0260635
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Diap1

Species
Drosophila melanogaster
Symbol
Diap1
Name
Death-associated inhibitor of apoptosis 1
Synonyms
  • 0736/01
  • 1065/03
Biotype
protein coding gene
Automated Description
Enables several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; enzyme binding activity; and ubiquitin-like protein ligase activity. Involved in several processes, including germ cell development; protein modification by small protein conjugation; and regulation of signal transduction. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; ganglia; germline cell; head epidermis primordium; and imaginal disc. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2) and BIRC3 (baculoviral IAP repeat containing 3).
FB Description
Death-associated inhibitor of apoptosis 1 (Diap1) encodes an E3 ubiquitin ligase with a caspase inhibitor activity that is involved in the control of apoptosis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10044
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            16.040M16.042M16.044M16.046M16.048M16.050M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Diap1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Diap1 role
              Diap1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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