Gene

par-1

Species
Drosophila melanogaster
Symbol
par-1
Name
par-1
Synonyms
  • 27C1
  • anon-WO0210402.19
Biotype
protein coding gene
Automated Description
Enables tau-protein kinase activity. Involved in several processes, including establishment of planar polarity; negative regulation of hippo signaling; and oogenesis. Located in several cellular components, including basolateral plasma membrane; fusome; and type I terminal bouton. Is expressed in several structures, including adult head; embryonic/larval anterior midgut; embryonic/larval fat body; fusome; and germline cell. Used to study neurodegenerative disease and visual impairment and progressive phthisis bulbi. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to several human genes including MARK1 (microtubule affinity regulating kinase 1) and MARK2 (microtubule affinity regulating kinase 2).
FB Description
par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24346
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
19.460M19.465M19.470M19.475M19.480M19.485M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions