Enables several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; TFIIA-class transcription factor complex binding activity; and chromatin binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in several processes, including autophagic cell death; mRNA transcription by RNA polymerase II; and spiracle morphogenesis, open tracheal system. Located in chromosome and germ cell nucleus. Is expressed in several structures, including cyst cell of testis; germline cell; midline glial cell; midline primordium; and pole plasm. Orthologous to human TBPL1 (TATA-box binding protein like 1).
FB Description
TATA box binding protein-related factor 2 (Trf2) encodes a core promoter recognition factor that mediates gene transcription. It contributes to spiracle morphogenesis, pupal development and salivary gland cell death.