Enables delayed rectifier potassium channel activity. Involved in several processes, including larval locomotory behavior; positive regulation of circadian sleep/wake cycle, sleep; and regulation of synaptic activity. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; epilepsy; and retinal cone dystrophy 3B. Orthologous to several human genes including KCNB2 (potassium voltage-gated channel subfamily B member 2).
FB Description
Shaker cognate b (Shab) encodes a member of the Sh family and the structural alpha subunit of a delayed rectifier K[+] channel (Kv2). The product of Shab channel functions to regulate excitability in neurons and muscles, and transmitter release.