Gene

Shab

Species
Drosophila melanogaster
Symbol
Shab
Name
Shaker cognate b
Synonyms
  • CG1066
  • CG43128
Biotype
protein coding gene
Automated Description
Enables delayed rectifier potassium channel activity. Involved in several processes, including larval locomotory behavior; positive regulation of circadian sleep/wake cycle, sleep; and regulation of synaptic activity. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; epilepsy; and retinal cone dystrophy 3B. Orthologous to several human genes including KCNB2 (potassium voltage-gated channel subfamily B member 2).
FB Description
Shaker cognate b (Shab) encodes a member of the Sh family and the structural alpha subunit of a delayed rectifier K[+] channel (Kv2). The product of Shab channel functions to regulate excitability in neurons and muscles, and transmitter release.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11537
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
2.90M2.91M2.92M2.93M2.94M2.95M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions