Gene

DnaJ-1

Species
Drosophila melanogaster
Symbol
DnaJ-1
Name
DnaJ-like-1
Synonyms
  • anon-WO0140519.166
  • anon-WO0172774.135
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor binding activity. Involved in positive regulation of crystal cell differentiation; protein stabilization; and response to heat. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anlage in statu nascendi; cuboidal/columnar epithelium; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in congenital myopathy 21. Orthologous to several human genes including DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5).
FB Description
DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24078
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
5.7502M5.7504M5.7506M5.7508M5.7510M5.7512M5.7514M5.7516M5.7518M5.7520M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions