Enables DNA-binding transcription factor binding activity. Involved in positive regulation of crystal cell differentiation; protein stabilization; and response to heat. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anlage in statu nascendi; cuboidal/columnar epithelium; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in congenital myopathy 21. Orthologous to several human genes including DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5).
FB Description
DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration.