Version: 8.0.0
Date: Tue Jan 28 2025
rdx
Drosophila melanogasterFB:FBgn0264493
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

rdx

Species
Drosophila melanogaster
Symbol
rdx
Name
roadkill
Synonyms
  • 0869/09
  • anon-WO0118547.577
Biotype
protein coding gene
Automated Description
Enables protein homodimerization activity and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including negative regulation of protein import into nucleus; regulation of protein metabolic process; and regulation of signal transduction. Located in nucleus. Part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior compartment boundary of imaginal disc; cuboidal/columnar epithelium; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human SPOP (speckle type BTB/POZ protein) and SPOPL (speckle type BTB/POZ protein like).
FB Description
roadkill (rdx) encodes a protein that functions as a substrate recognition component of Cul3-based E3 ubiquitin ligase complexes. It regulates the Hedgehog signaling pathway by promoting the degradation of the transcription factor encoded by ci.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24413
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            13.97M13.98M13.99M14.00M14.01M14.02M14.03M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            rdx molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              rdx role
              rdx genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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