Version: 8.0.0Date: Tue Jan 28 2025
Gene
Src42A
- Species
- Drosophila melanogaster
- Symbol
- Src42A
- Name
- Src oncogene at 42A
- Synonyms
- CG14471
- CG44128
- Biotype
- protein coding gene
- Automated Description
- Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including dorsal closure, spreading of leading edge cells; imaginal disc morphogenesis; and regulation of signal transduction. Located in cytoplasm and plasma membrane. Is expressed in several structures, including adult head; epithelial furrow; ganglia; imaginal disc; and tract. Used to study colorectal cancer and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; colorectal cancer (multiple); ductal carcinoma in situ; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to several human genes including FRK (fyn related Src family tyrosine kinase).
- FB Description
- Src oncogene at 42A (Src42A) encodes the none-receptor tyrosine kinase regulating cell proliferation, cell adhesion and morphogenetic processes including dorsal closure, tracheal tube size control and germ band elongation. It is regulated by both inhibitory and activating tyrosine phosphorylation.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24418
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr2R:5981844...6012795 + (30.95 kb)
- Assembly version
- R6
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.