Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in several processes, including muscle cell cellular homeostasis; myofibril assembly; and positive regulation of glycolytic process. Located in Z disc. Is expressed in embryonic dorsal epidermis; embryonic ventral epidermis; larval muscle system; and somatic muscle cell. Used to study autosomal recessive limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2H; and muscular dystrophy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2) and TRIM3 (tripartite motif containing 3).
FB Description
thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability.