Gene

tn

Species
Drosophila melanogaster
Symbol
tn
Name
thin
Synonyms
  • abba
  • Abba
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in several processes, including muscle cell cellular homeostasis; myofibril assembly; and positive regulation of glycolytic process. Located in Z disc. Is expressed in embryonic dorsal epidermis; embryonic ventral epidermis; larval muscle system; and somatic muscle cell. Used to study autosomal recessive limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2H; and muscular dystrophy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2) and TRIM3 (tripartite motif containing 3).
FB Description
thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24104
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
18.988M18.990M18.992M18.994M18.996M18.998M19.000M19.002M19.004M19.006M19.008M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions