Gene

Topors

Species
Drosophila melanogaster
Symbol
Topors
Name
Topoisomerase I-interacting protein
Synonyms
  • CG15104
  • dtopors
Biotype
protein coding gene
Automated Description
Enables lamin binding activity and ubiquitin protein ligase activity. Involved in several processes, including centrosome separation; male meiosis chromosome segregation; and meiotic chromosome condensation. Located in nuclear lamina and polytene chromosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase).
FB Description
Topoisomerase I-interacting protein (Topors) encodes a RING-finger containing putative dual Ubiquitin/SUMO ligase. It is required in the male germline for maintenance of nuclear shape and meiosis I chromosome segregation. It also targets ubiquitination of the developmental transcription factor encoded by hry.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46077
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
18.9730M18.9735M18.9740M18.9745M18.9750M18.9755M18.9760M18.9765M18.9770M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions