Enables lamin binding activity and ubiquitin protein ligase activity. Involved in several processes, including centrosome separation; male meiosis chromosome segregation; and meiotic chromosome condensation. Located in nuclear lamina and polytene chromosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase).
FB Description
Topoisomerase I-interacting protein (Topors) encodes a RING-finger containing putative dual Ubiquitin/SUMO ligase. It is required in the male germline for maintenance of nuclear shape and meiosis I chromosome segregation. It also targets ubiquitination of the developmental transcription factor encoded by hry.