Gene
vas
- Species
- Drosophila melanogaster
- Symbol
- vas
- Name
- vasa
- Synonyms
- BG:DS00929.14
- CG3506
- Biotype
- protein coding gene
- Automated Description
- Enables RNA helicase activity and mRNA 3'-UTR binding activity. Involved in several processes, including mitotic chromosome condensation; oogenesis; and regulation of gene expression. Located in several cellular components, including P granule; posterior cell cortex; and spectrosome. Is expressed in several structures, including egg chamber; germarium; germline cell; gonad; and gonadal sheath proper primordium. Orthologous to human DDX4 (DEAD-box helicase 4).
- FB Description
- vasa (vas) encodes Vasa (Vas) is a DEAD-box RNA helicase protein. It interacts with eIF5B and promotes translation of grk and mei-P26 mRNAs. Vas also functions in piRNA biogenesis as a component of an Amplifier complex. Maternally-expressed vas is required for oogenesis, transposon silencing in the female germ line, anterior-posterior embryonic patterning, and germ cell specification.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR47958
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr2L:15061656...15074311 + (12.66 kb)
- Assembly version
- R6
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Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.