Gene

FOSL1

Species
Homo sapiens
Symbol
FOSL1
Name
FOS like 1, AP-1 transcription factor subunit
Synonyms
  • FOS like 1, AP-1 trancription factor subunit
  • FOS like antigen 1
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription initiation and positive regulation of miRNA transcription. Located in nucleoplasm. Part of RNA polymerase II transcription regulator complex. Implicated in stomach cancer. Biomarker of cervical squamous cell carcinoma; colon adenocarcinoma; ductal carcinoma in situ; and tongue squamous cell carcinoma.
RGD Description
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23351
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          FOSL1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            FOSL1 role
            FOSL1 genetic perturbation
            Interactor gene
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            Interactor genetic perturbation
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            Phenotype or trait
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